Ghost Slayers Ayashi is a Japanese anime series, created and written by Shō Aikawa and produced by Bones. Directed by Hiroshi Nishikiori, it featured character designs by Toshihiro Kawamoto and premiered across Japan on October 7, 2006 on TBS's 6:00 pm doroku timeslot, which has previously occupied other noted anime Blood+, Fullmetal Alchemist and both series of the Gundam Seed franchise.

It received its satellite television premiere across Japan on Animax on November 14, 2006, and also received its English language television premiere on Animax's English networks across Southeast Asia and South Asia, Animax Asia, from January 2009. While originally scheduled to air for 52 episodes, the series' length was shortened to 25 due to its low ratings and ended its run on March 31, 2007.